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Long‐term potentiation in the avian hippocampus does not require activation of the N‐methyl‐D‐aspartate (NMDA) receptor
Author(s) -
Wieraszko Andrzej,
Ball Gregory F.
Publication year - 1993
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890130208
Subject(s) - nmda receptor , long term potentiation , kynurenic acid , neuroscience , hippocampus , stimulation , neural facilitation , facilitation , chemistry , synaptic potential , receptor , long term depression , excitatory postsynaptic potential , biology , ampa receptor , biochemistry , inhibitory postsynaptic potential
Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 × 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK‐801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long‐term potentiation, does not depend on the activation of NMDA receptors. © 1993 Wiley‐Liss, Inc.