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The GABA A receptor channel mediated chloride ion translocation through the plasma membrane: New insights from 36 Cl − ion flux measurements
Author(s) -
Kardos J.
Publication year - 1993
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890130110
Subject(s) - chemistry , chloride channel , ion channel , gabaa receptor , biophysics , membrane , chloride , ion , receptor , kinetics , flux (metallurgy) , biochemistry , biology , organic chemistry , physics , quantum mechanics
GABA A receptors in plasma membranes of neurons are integral oligomers which form chloride channels. The binding of GABA molecules at recognition sites for channel opening triggers a transient increase in transmembrane chloride ion flux. The multiplicity and drug specificity of GABA A receptor, kinetics of channel opening, and desensitization of GABA A receptor and its short‐ and long‐term regulation have been investigated by the use of tracer amounts of the radioactive chloride isotope, 36 Cl − ion. Results and new insights from 36 Cl − ion flux measurements have been reviewed. © 1993 Wiley‐Liss, Inc.