In vivo studies of [ 125 I]iodobenzamide and [ 11 C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D 2  dopamine receptors | Zendy

Wong Dean F. | Zendy; Wilson Alan A. | Zendy; Chen Catherine | Zendy; Minkin Elynne | Zendy; Dannals Robert F. | Zendy; Ravert Hayden T. | Zendy; SanchezRoa Patricia | Zendy; Villemagne Victor | Zendy; Wagner Henry N. | Zendy

Premium

In vivo studies of [ 125 I]iodobenzamide and [ 11 C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D 2 dopamine receptors

Author(s) -

Wong Dean F.,

Wilson Alan A.,

Chen Catherine,

Minkin Elynne,

Dannals Robert F.,

Ravert Hayden T.,

SanchezRoa Patricia,

Villemagne Victor,

Wagner Henry N.

Publication year - 1992

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.890120309

Subject(s) - raclopride , in vivo , positron emission tomography , biodistribution , preclinical imaging , ligand (biochemistry) , chemistry , brain positron emission tomography , biophysics , dopamine receptor d2 , pharmacology , nuclear medicine , receptor , biology , biochemistry , medicine , microbiology and biotechnology

Iodobenzamide (IMB) labeled with either [ 11 C] or [ 125 I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D 2 dopamine receptors. Mouse biodistribution studies with both [ 11 C]IMB and [ 125 I]IMB showed a similar brain distribution of radioactivity. Mouse [ 125 I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D 2 receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research