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Involvement of the nigrotectal and nigrothalamic pathways in kappa opioid‐induced circling
Author(s) -
Thompson Lisa A.,
Walker J. Michael
Publication year - 1992
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890120303
Subject(s) - ibotenic acid , κ opioid receptor , neuroscience , microinjection , striatum , substantia nigra , kappa , pars reticulata , opioid , endogenous opioid , chemistry , psychology , basal ganglia , medicine , receptor , globus pallidus , central nervous system , dopamine , biochemistry , linguistics , philosophy , dopaminergic
The relationship between kappa opioid‐induced movement and output stations of the substantia nigra pars reticulata (SNpr) was examined using the rodent circling model. Contralateral rotation produced by intranigral microinjection of the kappa opiate U50,488 was lower in animals with ibotenic acid lesions of either the ipsilateral ventromedial thalamus or superior colliculas than in control animals without lesions. These results suggest that endogenous kappa opioids in the SNpr may influence movement through action on the nigrothalamic and nigrotectal pathways. In contrast, animals with ipsilateral lesions of the striatum showed an increase in circling relative to controls, possibly due to kappa receptor supersensitivity in the SNpr. © 1992 Wiley‐Liss, Inc.