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Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo
Author(s) -
Maren Stephen,
Baudry Michel,
Thompson Richard F.
Publication year - 1992
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890110307
Subject(s) - dentate gyrus , long term potentiation , excitatory postsynaptic potential , population spike , nmda receptor , neuroscience , perforant path , chemistry , ampa receptor , postsynaptic potential , ltp induction , pharmacology , biology , receptor , hippocampus , inhibitory postsynaptic potential , biochemistry
The effects of the novel competitive N ‐methyl‐ D ‐aspartate (NMDA) receptor antagonist, CGP 39551 [the carboxyethylester of CGP 37849; DL ‐(E)‐2‐amino‐4‐methy‐5‐phosphono‐3‐pentenoic acid], on extracellular field potentials and long‐term potentiation (LTP) induced in the dentate gyrus by stimulation of the perforant path were studied in anesthetized rats. CGP 39551 attenuated the population spike (PS) and excitatory postsynaptic potential (EPSP) amplitude of dentate field potentials, reduced the NMDA receptor‐mediated component of train‐evoked burst potentials, and prevented the induction of LTP. The decrease in PS and EPSP amplitude produced by CGP 39551 was observed mainly in non‐potentiated synaptic populations; potentiated field potentials were only minimally affected by drug treatment. These results are consistent with the in vivo blockade of NMDA receptors by CGP 39551. They also indicate that NMDA receptors may contribute in a tonic manner to the state of dentate granule cell excitability. Finally, the differential modulation of potentiated and non‐potentiated synapses by CGP 39551 suggests that a change in some properties of postsynaptic AMPA receptors is involved in the expression of LTP. © Wiley‐Liss, Inc.