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Regional norepinephrine response to amphetamine using dialysis: Comparison with caudate dopamine
Author(s) -
Kuczenski Ronald,
Segal David S.
Publication year - 1992
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890110210
Subject(s) - amphetamine , norepinephrine , dopamine , hippocampus , medicine , prefrontal cortex , endocrinology , neuroscience , psychology , anesthesia , pharmacology , cognition
The response of extracellular norepinephrine to the acute administration of amphetamine was assessed, using dialysis, in prefrontal cortex and hippocampus in awake, behaving rats. Norepinephrine exhibited a pronounced and rapid dose‐ and time‐dependent increase in response to 0.5 and 2.5 mg/kg amphetamine, which corresponded closely to the time course of the behavioral profile. These results are consistent in with a possible role for norepinephrine in the behavioral response to amphetamine. © Wiley‐Liss, Inc.