Regional norepinephrine response to amphetamine using dialysis: Comparison with caudate dopamine | Zendy

Kuczenski Ronald | Zendy; Segal David S. | Zendy

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Regional norepinephrine response to amphetamine using dialysis: Comparison with caudate dopamine

Author(s) -

Kuczenski Ronald,

Segal David S.

Publication year - 1992

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.890110210

Subject(s) - amphetamine , norepinephrine , dopamine , hippocampus , medicine , prefrontal cortex , endocrinology , neuroscience , psychology , anesthesia , pharmacology , cognition

The response of extracellular norepinephrine to the acute administration of amphetamine was assessed, using dialysis, in prefrontal cortex and hippocampus in awake, behaving rats. Norepinephrine exhibited a pronounced and rapid dose‐ and time‐dependent increase in response to 0.5 and 2.5 mg/kg amphetamine, which corresponded closely to the time course of the behavioral profile. These results are consistent in with a possible role for norepinephrine in the behavioral response to amphetamine. © Wiley‐Liss, Inc.

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