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Dissociative anesthesia and striatal neuronal electrophysiology
Author(s) -
Kelland Mark D.,
Chiodo Louis A.,
Freeman Arthur S.
Publication year - 1991
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890090111
Subject(s) - chloral hydrate , stimulation , anesthetic , chemistry , neuroscience , electrophysiology , ketamine , premovement neuronal activity , basal ganglia , cortical neurons , neuron , anesthesia , psychology , central nervous system , medicine
Compared with results obtained in locally anesthetized, paralyzed rats, the dissociative anesthetic ketamine did not alter either the number of spontaneously active striatal neurons or the basal firing rate of striatal neurons; 90% of these cells exhibited the type I striatal neuron waveform. Chloral hydrate anesthesia suppressed both the occurrence and the firing rate of spontaneously active type I cells, but did not alter the activity of type II striatal neurons. Cortical stimulation preferentially activated type II cells in paralyzed rats and in chloral hydrate‐anesthetized rats. Thus, under dissociative anesthesia it is possible to study spontaneously active type I striatal neurons. However, a method of activation such as cortical stimulation is necessary to study type II striatal neurons.