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The benzodiazepine receptor inverse agonist DMCM decreases serotonergic transmission in rat hippocampus: An in viovo electrophysiological study
Author(s) -
Lista Alvaro,
Blier Pierre,
De Montigny Claude
Publication year - 1990
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890060209
Subject(s) - inverse agonist , agonist , chemistry , benzodiazepine , pharmacology , flumazenil , hippocampus , partial agonist , gabaa receptor , receptor , medicine , biochemistry
The intravenous administration of the benzodiazepine inverse agonist DMCM (6,7‐dimethoxy‐4‐ethyl‐β‐carboline‐3‐carboxylic acid methyl ester) dose‐dependently reduced the efficacy of electrial stimulation of the 5‐HT pathway in depressing the firing activity of rat hippocampus pyramidal neurons. This effect was prevented by the benzodiazepine receptor antagonist flumazenil and reversed by the benzodiazepine receptor agonist diazepam. This indicates that DMCM alters‐5HT transmission in the rat dorsal hippocampus via benzodiazepine receptors and that these receptors have both agonist and inverse agonist sites.