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Pargyline‐Sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia
Author(s) -
Efange S. M. N.,
Kung H. F.,
Mash D. C.,
Jabir M.,
Billings J.,
Pablo J.,
Dutta A.,
Freshler A.
Publication year - 1990
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890050306
Subject(s) - pargyline , mptp , caudate nucleus , putamen , basal ganglia , substantia nigra , chemistry , cerebellum , monoamine oxidase , endocrinology , medicine , dopamine , neuroscience , central nervous system , biochemistry , biology , dopaminergic , enzyme
The distribution of radioiodinated N‐methyl‐4‐(4‐hyroxy‐3‐iodobenzyl)‐1,2,3,6‐tetrahydropyridine (MHTP), an analog of the reportedly nontoxic N‐methyl‐4‐benzyl‐1,2,3,6‐tetrahydropyridine, (4‐homo‐MPTP), has been studied in the primate. [ 123 I]‐MHTP‐derived radioactivity exhibited a progressive accumulation and prolonged retention within the primateeye. Following injection, [ 123 I]MHTP rapidly accumulated within the primate brain and was subssequently oxidized to a radiolabeled metabolite. The half‐life of [ 123 I]MHTP‐derived radioactivity within the primate brain was 50 min. The highest concentrations of radioactivity were found in the caudate‐putamen and the frontal, temproal and cingulate cortices; the substantia nigra and inferior olivary nucleus were labeled with medium intensity. Very low concentrations of radiolabel were detected in the cerebellum and white matter, Selective accumulation of [ 125 I]MHTP‐derived radioactivity within these structures was blocked by pretreatment with pargyline, suggesting that nonoamine oxidase B is involved in the bioactivation of radioiodinated MHTP.