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The Akaike information criterion (AIC) is not a sufficient condition to determine the number of ion channel states from single channel recordings
Author(s) -
Liebovitch Larry S.,
Tóth Tibor I.
Publication year - 1990
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890050207
Subject(s) - akaike information criterion , channel (broadcasting) , statistics , bayesian information criterion , mathematics , computer science , telecommunications
The Akaike information criterion (AIC) and other criteria that trade off the goodness‐of‐fit against the number of parameters have been used to determine the number of ion channel states from single channel recordings. We show that, in general, such criteria are not valid. This is illustrated by an elementary example in which the AIC yields an incorrect result. The implications of these findings for the discrimination of different kinetic models of ion channels are discussed.