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Substantia nigra 6‐hydroxydopamine lesions alter dopaminergic synaptic markers in the nucleus basalis magnocellularis and striatum of rats
Author(s) -
Geula Changiz,
Slevin John T.
Publication year - 1989
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890040310
Subject(s) - substantia nigra , pars compacta , striatum , neuroscience , basal ganglia , hydroxydopamine , dopaminergic , dopamine , nucleus basalis , nigrostriatal pathway , endocrinology , medicine , chemistry , psychology , basal forebrain , central nervous system
Recent findings have demonstrated the existence of dopaminergic (DA) markers in the nbM of the human brain and a reduction of these markers in both the nbM and the striatum of patients suffering from Alzheimer's disease (AD). To investigate the source of the DA synaptic markers found in the nbM, rats received unilateral 6‐OHDA lesions of the substantia nigra pars compacta (SNc). The SNc lesions caused signigificant reductions in DA and DOPAC but not HVA in the nbM and the striaum; 3 H‐sulpiride binding to D 2 receptors ipsilateral to the SNc lesion was significantly increased in the stratum (16%), consistent with denervation supersensitivity, but single‐point analysis showed no significant changes in the nbM. These data suggest that the decreases in DA and 3 H‐spiperone binding levels observed in the nbM of AD patients may be due to partial destruction of DA nbM afferent projections from the brainstem.