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Concentrations of mRNAs encoding for preprosomatostatin and preprocholecystokinin are increased after kainic acid‐induced seizures
Author(s) -
Olenik C.,
Meyer D. K.,
Marksteiner J.,
Sperk G.
Publication year - 1989
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890040307
Subject(s) - kainic acid , encoding (memory) , neuroscience , chemistry , microbiology and biotechnology , pharmacology , biochemistry , biology , glutamate receptor , receptor
Abstract Concentrations of preprosomatostatin‐mRNA and preprocholecystokinin‐mRNA were determined by Northern blot analysis in rats 2, 10, and 30 days after strong seizures induced by a single intraperitoneal injection of kainic acid. At all time intervals examined, levels of preprosomatostatin‐mRNA were increased in the frontal cortex; so were levels of preprosomatostatin‐mRNA in the striatum. Transient increases, i.e., 2 days after kainic acid, of preprocholecystokinin‐mRNA were observed in the frontal cortex and the substantia nigra. Preprocholecystokinin‐mRNA was reduced in the hippocampus 2 and 10 days after kainic acid. Both preprosomatostatin‐ and preprocholecystokinin‐mRNA levels showed a tendency to be reduced in the amygdala/pyriform cortex at all three time intervals. The increases in mRNA levels suggest enhanced rates of synthesis of the respective neuropeptides subsequent to kainic acid‐induced seizures. They may also reflect a prolonged increase in the activity of the respective peptide‐containing neurons. This is of special interest in the frontal cortex, since in this area both neuropeptides are found in interneurons and are widely colocalized with γ‐aminobutyric acid.

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