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Serotoninergic neurites in senile plaques in cingulate cortex of aged nonhuman primate
Author(s) -
Kitt Cheryl A.,
Walker Lary C.,
Molliver Mark E.,
Price Donald L.
Publication year - 1989
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890030103
Subject(s) - primate , neurite , neuroscience , serotonergic , nonhuman primate , cingulate cortex , cortex (anatomy) , anterior cingulate cortex , biology , medicine , psychology , serotonin , central nervous system , evolutionary biology , receptor , biochemistry , cognition , in vitro
In immunocytochemical studies, a polyclonal antiserotonin antibody was used to visualize fibers within the cingulate cortex of young and aged rhesus monkeys. Intricate and distinct patterns of serotoninergic processes were seen in anterior and posterior segments of cingulate cortex (Brodmann areas 24 and 23). In these regions of cortex, many multivaricose serotonin‐immunoreactive axonal swellings were identified, and some of these immunostained neurites were associated with deposits of amyloid. These observations suggest that serotoninergic processes are involved in the formation of senile plaques in neocortex of aged macaques.