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Adaptive changes of β‐adrenergic receptors after neonatal locus coeruleus lesion: Regulation of serotoninergic unit activity
Author(s) -
Lanfumey Laurence,
Adrien Joëlle
Publication year - 1988
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890020611
Subject(s) - locus coeruleus , dorsal raphe nucleus , serotonergic , autoreceptor , lesion , adrenergic receptor , neuroscience , propranolol , premovement neuronal activity , receptor , endocrinology , medicine , inhibitory postsynaptic potential , adrenergic , chemistry , biology , nucleus , serotonin , pathology
Spontaneous activity of 5‐hydroxytryptamine (5‐HT) neurons in the dorsal raphe nucleus (DRN) was recorded in adult rats that had undergone a bilateral locus coeruleus (LC) lesion during the neonatal period. The susceptibility of this neuronal firing to β‐adrenergic manipulation was tested. Microiontophoretic application of the β‐blockers d,l‐propranolol and acebutolol inhibited the firing of DRN cells in lesioned rats but not in control animals. This effect was specific to β‐receptors since the effects of pharmacological manipulation of other receptors—5‐HT, γ‐aminobutyric acid (GABA), γ‐adrenoceptors— were identical in lesioned and control animals. The present data demonstrate that a neonatal noradrenergic lesion allowed the persistence of a β‐regulation of DRN neuronal firing, which in young rats is normally only transient.