Premium
Immunocytochemical evidence for substance P and serotonin input to medullary bulbospinal adrenergic neurons
Author(s) -
Nicholas Anthony P.,
Hancock Michael B.
Publication year - 1988
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890020602
Subject(s) - serotonin , substance p , neuroscience , adrenergic , medullary cavity , chemistry , biology , medicine , receptor , neuropeptide
Using two‐color immunoperoxidase staining combined with the retrograde transport of horseradish peroxidase injected into the rostral thoracic spinal cord, substance P‐immunoreactive (SPI) and serotonin‐immunoreactive (5HTI) variocosities have been observed in contiguity with medullary bulbospinal phenylethanolamine N‐methyl transferase‐immunoreactive (PNMTI) neurons of the C1, C2, and C3 cell groups. Since PNMTI terminals in the spinal cord are concentrated among sympathetic preganglionic neurons (SPGN) in the intermediolateral cell column, the close anatomical associations shown in the present study indicate that substance P‐ and serotonin‐containing pathways in the medulla likely affect activity of SPGN via adrenergic bulbospinal neurons.