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Biochemical and behavioral effects of sigma and PCP ligands
Author(s) -
Contreras Patricia C.,
Contreras Margarita L.,
L. O'donohue Thomas,
Lair Cecelia C.
Publication year - 1988
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890020311
Subject(s) - sigma receptor , sigma 1 receptor , receptor , sigma , sniffing , chemistry , pharmacology , biology , neuroscience , biochemistry , agonist , physics , quantum mechanics
The purpose of this study was to examine the binding and behavioral effects mediated by PCP and sigma receptors in the rat. From the radioreceptor assays, it was possible to characterize two binding sites that interact with PCP and sigma ligands. The two sites, a PCP and sigma receptor, could be differentiated based on drug selectivity and potency. In the behavioral assays, MK‐801, which bound preferentially to the PCP receptor, and 1,3‐di‐O‐tolylguanidine, which bound preferentially to the sigma receptor, induced sniffing, rearing, circling, backpedaling, and weaving behavior. These results indicate that there are distinct PCP and sigma receptors that are both involved in mediating stereotyped behavior and ataxia in the rat.