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Human brain dopamine receptors in children and aging adults
Author(s) -
Seeman Philip,
Bzowej Natalie H.,
Guan H.C.,
Bergeron Catherine,
Becker Lawrence E.,
Reynolds Gavin P.,
Bird E. D.,
Riederer Peter,
Jellinger Kurt,
Watanabe Shuzo,
Tourtellotte Wallace W.
Publication year - 1987
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.890010503
Subject(s) - dopamine , receptor , dopamine receptor , striatum , neuroscience , human brain , d 1 , medicine , endocrinology , psychology
Since spontaneous oral dyskinesias are more prevalent in the elderly, and since these movements may be controlled by the balance of brain dopamine D 1 and D 2 dopamine receptors, we measured the densities of these receptors in 247 postmortem brain striata. In childhood, the densities of D 1 and D 2 dopamine receptors in the brain striatum rise and fall together. After age 20 years, D 1 receptors disappear at 3.2% per decade while D 2 receptors disappear at about 2.2% per decade. Overall, therefore, the D 1 /D 2 ratio falls with age. Since perioral motion in rats is dominated by a high D 1 /D 2 ratio, the observed decline in the human D 1 /D 2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different.