Premium
Gallic acid improves recognition memory and decreases oxidative‐inflammatory damage in the rat hippocampus with metabolic syndrome
Author(s) -
Diaz Alfonso,
MuñozArenas Guadalupe,
CaporalHernandez Karen,
VázquezRoque Rubén,
LopezLopez Gustavo,
Kozina Anna,
Espinosa Blanca,
Flores Gonzalo,
Treviño Samuel,
Guevara Jorge
Publication year - 2021
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.22186
Subject(s) - oxidative stress , neuroprotection , hippocampus , metabolic syndrome , neurodegeneration , memory improvement , dyslipidemia , inflammation , medicine , dementia , hippocampal formation , endocrinology , insulin resistance , gallic acid , antioxidant , pharmacology , diabetes mellitus , biology , biochemistry , cognition , psychiatry , disease
Metabolic syndrome (MS) results from excessive consumption of high‐calorie foods and sedentary lifestyles. Clinically, insulin resistance, abdominal obesity, hyperglycemia, dyslipidemia, and hypertension are observed. MS has been considered a risk factor in the development of dementia. In the brain, a metabolically impaired environment generates oxidative stress and excessive production of pro‐inflammatory cytokines that deteriorate the morphology and neuronal function in the hippocampus, leading to cognitive impairment. Therapeutic alternatives suggest that phenolic compounds can be part of the treatment for neuropathies and metabolic diseases. In recent years, the use of Gallic Acid (GA) has demonstrated antioxidant and anti‐inflammatory effects that contribute to neuroprotection and memory improvement in animal models. However, the effect of GA on hippocampal neurodegeneration and memory impairment under MS conditions is still unclear. In this work, we administered GA (20 mg/kg) for 60 days to rats with MS. The results show that GA treatment improved zoometric and biochemical parameters, as well as the recognition memory, in animals with MS. Additionally, GA administration increased hippocampal dendritic spines and decreased oxidative stress and inflammation. Our results show that GA treatment improves metabolism: reducing the oxidative and inflammatory environment that facilitates the recovery of the neuronal morphology in the hippocampus of rats with MS. Consequently, the recognition of objects by these animals, suggesting that GA could be used therapeutically in metabolic disorders that cause dementia.