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In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol
Author(s) -
Deal Alex L.,
Mikhailova Maria A.,
Grinevich Valentina P.,
Weiner Jeff L.,
Gainetdinov Raul R.,
Budygin Evgeny A.
Publication year - 2019
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.22080
Subject(s) - locus coeruleus , norepinephrine , catecholamine , dopamine , infralimbic cortex , stimulation , prefrontal cortex , neuroscience , dopaminergic , chemistry , medicine , psychology , central nervous system , cognition
Using fast‐scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and not affected by acute ethanol. With previous work, these data suggest differential effects of ethanol on prefrontal norepinephrine and dopamine, a region important in addiction‐related pathways.