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Neuroprotective effects of extracellular DJ ‐1 on reperfusion injury in SH ‐ SY 5 Y cells
Author(s) -
Han Jay,
Luk Beryl,
Lee Frank J.S.
Publication year - 2017
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21963
Subject(s) - propidium iodide , neuroprotection , extracellular , programmed cell death , chemistry , apoptosis , reperfusion injury , microbiology and biotechnology , in vitro , pharmacology , ischemia , biochemistry , biology , medicine
Using an in vitro model of ischemic stroke we treated differentiated SH‐SY5Y cells to oxygen‐glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ‐1 during reperfusion exhibited significant rescue from OGD‐induced cell death.