Neuroprotective effects of extracellular  DJ ‐1 on reperfusion injury in  SH ‐ SY 5 Y  cells | Zendy

Han Jay | Zendy; Luk Beryl | Zendy; Lee Frank J.S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Neuroprotective effects of extracellular DJ ‐1 on reperfusion injury in SH ‐ SY 5 Y cells

Author(s) -

Han Jay,

Luk Beryl,

Lee Frank J.S.

Publication year - 2017

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.21963

Subject(s) - propidium iodide , neuroprotection , extracellular , programmed cell death , chemistry , apoptosis , reperfusion injury , microbiology and biotechnology , in vitro , pharmacology , ischemia , biochemistry , biology , medicine

Using an in vitro model of ischemic stroke we treated differentiated SH‐SY5Y cells to oxygen‐glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ‐1 during reperfusion exhibited significant rescue from OGD‐induced cell death.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research