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Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol‐induced seizures in zebrafish
Author(s) -
PiseraFuster Antonella,
Otero Sofía,
Talevi Alan,
BrunoBlanch Luis,
Bernabeu Ramón
Publication year - 2017
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21961
Subject(s) - propylparaben , pentylenetetrazol , anticonvulsant , zebrafish , pharmacology , chemistry , sodium channel , anticonvulsant drugs , epilepsy , sodium , seizure threshold , methylparaben , medicine , neuroscience , biology , biochemistry , preservative , organic chemistry , gene
Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost‐efficient preclinical models applicable to high‐throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)‐induced seizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.