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The selective dopamine D 3 receptor antagonist SB ‐277011‐ A significantly decreases binge‐like consumption of ethanol in C 57 BL / J 6 mice
Author(s) -
Rice Onarae V.,
Schonhar Charles A.,
Gaál J.,
Gardner Eliot L.,
Ashby Charles R.
Publication year - 2015
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21816
Subject(s) - chemistry , ethanol , antagonist , dopamine , receptor , biology , biochemistry , neuroscience
The authors show that the dopamine D3 antagonist SB‐277011‐A consistently and persistently decrease binge‐like EtOH consumption at 30 mg/kg and it decreases binge‐like consumption on days 3, 7, 9, and 11–13 at 15 mg/kg. These findings suggest that the brain's D3 receptor may also be involved in not only ethanol reward but binge drinking as well. Synapse 69:295–298, 2015 . © 2015 Wiley Periodicals, Inc.