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Detection of monoamine oxidase a in brain of living rats with [ 18 F]fluoroethyl‐harmol PET
Author(s) -
Cumming Paul,
Skaper Dirk,
Kuwert Torsten,
Maschauer Simone,
Prante Olaf
Publication year - 2015
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21785
Subject(s) - harmine , monoamine oxidase , chemistry , ligand (biochemistry) , monoamine oxidase a , monoamine oxidase b , radioligand , biochemistry , enzyme , binding site , neuroscience , psychology , receptor
The efficient radiosynthesis for the MAO‐A ligand [ 18 F]fluoroethyl‐harmol is reported. Initial PET examinations reveal the ligand to be retained throughout rat brain during 90 min, whereas pretreatment with pargyline results in substantially increased washout, from which binding potentials in the range of 1.4–2.1 can be calculated.