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No correlation between serotonin and its metabolite 5‐HIAA in the cerebrospinal fluid and [ 11 C]AZ10419369 binding measured with PET in healthy volunteers
Author(s) -
Tiger Mikael,
Svenningsson Per,
Nord Magdalena,
Jabre Sandra,
Halldin Christer,
Lundberg Johan
Publication year - 2014
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21761
Subject(s) - cerebrospinal fluid , serotonin , metabolite , binding potential , chemistry , pharmacology , medicine , endocrinology , receptor
[ 11 C]AZ10419369 is sensitive to pharmacologically enhanced endogenous serotonin levels. Twelve healthy volunteers underwent [ 11 C]AZ10419369 PET and lumbar puncture. There were no correlations between [ 11 C]AZ10419369 binding and concentrations of serotonin and its metabolite 5‐HIAA in cerebrospinal fluid, suggesting that [ 11 C]AZ10419369 brain binding does not reflect baseline serotonin levels in cerebrospinal fluid.