No correlation between serotonin and its metabolite 5‐HIAA in the cerebrospinal fluid and [ 11 C]AZ10419369 binding measured with PET in healthy volunteers | Zendy

Tiger Mikael | Zendy; Svenningsson Per | Zendy; Nord Magdalena | Zendy; Jabre Sandra | Zendy; Halldin Christer | Zendy; Lundberg Johan | Zendy

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No correlation between serotonin and its metabolite 5‐HIAA in the cerebrospinal fluid and [ 11 C]AZ10419369 binding measured with PET in healthy volunteers

Author(s) -

Tiger Mikael,

Svenningsson Per,

Nord Magdalena,

Jabre Sandra,

Halldin Christer,

Lundberg Johan

Publication year - 2014

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.21761

Subject(s) - cerebrospinal fluid , serotonin , metabolite , binding potential , chemistry , pharmacology , medicine , endocrinology , receptor

[ 11 C]AZ10419369 is sensitive to pharmacologically enhanced endogenous serotonin levels. Twelve healthy volunteers underwent [ 11 C]AZ10419369 PET and lumbar puncture. There were no correlations between [ 11 C]AZ10419369 binding and concentrations of serotonin and its metabolite 5‐HIAA in cerebrospinal fluid, suggesting that [ 11 C]AZ10419369 brain binding does not reflect baseline serotonin levels in cerebrospinal fluid.

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