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Cortical dopamine release during a behavioral response inhibition task
Author(s) -
Albrecht Daniel S.,
Kareken David A.,
Christian Bradley T.,
Dzemidzic Mario,
Yoder Karmen K.
Publication year - 2014
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21736
Subject(s) - orbitofrontal cortex , precuneus , neuroscience , psychology , middle frontal gyrus , dopamine , superior frontal gyrus , impulsivity , cingulate cortex , stop signal , precentral gyrus , prefrontal cortex , cognition , medicine , central nervous system , developmental psychology , engineering , latency (audio) , magnetic resonance imaging , electrical engineering , radiology
ABSTRACT Dopamine (DA) dysregulation within fronto‐striatal circuitry may underlie impulsivity in alcohol and other substance use disorders. To date, no one has directly demonstrated DA release during a task requiring the control of impulsive behavior. The current study was conducted to determine whether a response inhibition task (stop signal task; SST) would elicit detectable extrastriatal DA release in healthy controls. We hypothesized that DA release would be detected in regions previously implicated in different aspects of inhibitory control. [ 18 F]Fallypride (FAL) PET imaging was performed in nine healthy males (24.6 ± 4.1 y.o.) to assess changes in cortical DA during a SST relative to a baseline “Go” task. On separate days, subjects received one FAL scan during the SST, and one FAL scan during a “Go” control; task‐order was counter‐balanced across subjects. Parametric BP ND images were generated and analyzed with SPM8. Voxel‐wise analysis indicated significant SST‐induced DA release in several cortical regions involved in inhibitory control, including the insula, cingulate cortex, orbitofrontal cortex, precuneus, and supplementary motor area. There was a significant positive correlation between stop signal reaction time and DA release in the left orbitofrontal cortex, right middle frontal gyrus, and right precentral gyrus. These data support the feasibility of using FAL PET to study DA release during response inhibition, enabling investigation of relationships between DA function and impulsive behavior. Synapse 68:266–274, 2014 . © 2014 Wiley Periodicals, Inc.