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Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5‐HT7‐Rs in naples high excitability rats
Author(s) -
Ruocco Lucia A.,
Romano Emilia,
Treno Concetta,
lacivita Enza,
Claudio Arra,
GironiCarnevale Ugo A.,
Travaglini Domenica,
Leopoldo Marcello,
Laviola Giovanni,
Sadile Adolfo G.,
Adriani Walter
Publication year - 2014
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21724
Subject(s) - disinhibition , stimulation , dose , agonist , dopaminergic , medicine , endocrinology , 5 ht receptor , psychology , serotonin , pharmacology , receptor , psychiatry , dopamine
We report here the results of studies aimed to investigate the involvement of serotonin receptor 7 subtype (5‐HT7‐R) in the modulation of emotional response in Naples High‐Excitability (NHE) rat, a validated model for hyperactivity and impaired attention. A range of dosages (0.0, 0.125, 0.250, or 0.500 mg/kg) of LP‐211, a selective agonist of 5‐HT7‐Rs, has been evaluated in animals at different age (adolescence and adulthood). Male NHE and random bred (NRB) control rats were tested in an Elevated Zero‐Maze (EZM) after LP‐211 treatment in two different regimens: at the issue of adolescent, subchronic exposure (14 intraperitoneal [i.p.] injections, once/day, pnd 31–44, tested on pnd 45—Exp. 1) or as adult, acute effect (15 min after i.p. injection—Exp. 2). Adolescent, subchronic LP‐211 at 0.500 mg/kg dosage increased the frequency of head‐dips only in NHE rats. Drug effect on time spent and entries in open EZM quadrants were revealed with adult, acute administration of 0.125 mg/kg LP‐211 (both strains), indicating a tendency toward anxiolytic effects. In conclusion, data demonstrate that subchronic stimulation of 5‐HT7‐Rs during prepuberal period increases novelty‐seeking/risk‐taking propensity in NHE adults. These sequels are revealing increased disinhibition and/or motivation to explore in the NHE rats, which are characterized by a hyperactive dopaminergic system. These data may open new perspectives in studying mechanism of risk‐seeking behavior. Synapse 68:159–167, 2014 . © 2013 Wiley Periodicals, Inc.