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No change in [ 11 C]CUMI‐101 binding to 5‐HT 1A receptors after intravenous citalopram in human
Author(s) -
Pinborg Lars H.,
Feng Ling,
Haahr Mette E.,
Gillings Nic,
Dyssegaard Agnete,
Madsen Jacob,
Svarer Claus,
Yndgaard Stig,
Kjaer Troels W.,
Parsey Ramin V.,
Hansen Hanne D.,
Ettrup Anders,
Paulson Olaf B.,
Knudsen Gitte M.
Publication year - 2012
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21579
Subject(s) - citalopram , receptor , chemistry , pharmacology , medicine , nuclear medicine , endocrinology , serotonin , biochemistry
Abstract The main objective of this study was to determine the sensitivity of [ 11 C]CUMI‐101 to citalopram challenge aiming at increasing extracellular 5‐HT. CUMI‐101 has agonistic properties in human embryonic kidney 293 cells transfected with human recombinant 5‐HT 1A receptors (Hendry et al. [2011] Nucl Med Biol 38:273–277; Kumar et al. [2006] J Med Chem 49:125–134) and has previously been demonstrated to be sensitive to bolus citalopram in monkeys (Milak et al. [2011] J Cereb Blood Flow Metab 31:243–249). We studied six healthy individuals. Two PET‐scans were performed on the same day in each individual before and after constant infusion of citalopram (0.15 mg/kg). The imaging data were analyzed using two tissue compartment kinetic modeling with metabolite corrected arterial input and Simplified Reference Tissue Modeling using cerebellum as a reference region. There was no significant difference in regional distribution volume or non‐displaceable binding potential values before and after citalopram infusion. The mean receptor occupancy was 0.03 (range −0.14 to 0.17). Our data imply that [ 11 C]CUMI‐101 binding is not sensitive to citalopram infusion in humans. Synapse, 2012. © 2012 Wiley Periodicals, Inc.