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Mice lacking neuropeptide Y show increased sensitivity to cocaine
Author(s) -
Sørensen Gunnar,
Woldbye David P.D.
Publication year - 2012
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21568
Subject(s) - anxiogenic , neuropeptide y receptor , dopamine transporter , addiction , dopamine , knockout mouse , neuropeptide , genetically modified mouse , neuroscience , transgene , psychology , endocrinology , pharmacology , medicine , biology , anxiety , receptor , dopaminergic , psychiatry , gene , anxiolytic , genetics
There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine‐induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined. Synapse 66:840–843, 2012. © 2012 Wiley Periodicals, Inc.