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D 1 –NMDA receptor interactions in the rat nucleus accumbens change during adolescence
Author(s) -
HuppéGourgues Frédéric,
O'donnell Patricio
Publication year - 2012
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.21544
Subject(s) - nucleus accumbens , nmda receptor , agonist , neuroscience , medium spiny neuron , glutamate receptor , striatum , prefrontal cortex , dopamine , chemistry , psychology , receptor , cognition , biochemistry
Many aspects of the dopamine (DA) system mature during adolescence. For example, the DA modulation of glutamate responses in the rat prefrontal cortex (PFC) acquires adult characteristics during late adolescence. In the striatum, D 1 receptors modulate NMDA responses, but whether this behaviorally important interaction matures during adolescence is not known. Here, we tested whether the D 1 agonist SKF38393 affects NMDA actions on nucleus accumbens medium spiny neuron (MSN) excitability in slices from juvenile and young adult rats. NMDA dose‐dependently increased excitability in both age groups, and the D 1 agonist produced a marginal increase of MSN excitability. In juvenile slices, the most common interaction was a downregulation of NMDA effects on excitability by the D 1 agonist, whereas in most adult MSN, the D 1 agonist increased NMDA effects on MSN excitability. These results suggest that D 1 –NMDA receptor interactions in the nucleus accumbens change during adolescence, a change that may result in different processing of reward functions during this critical developmental stage. Synapse, 2012. © 2012 Wiley Periodicals, Inc.