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Regulation of type 1 inositol 1,4,5‐triphosphate receptor by dopamine receptors in cocaine‐induced place conditioning
Author(s) -
Kurokawa Kazuhiro,
Mizuno Koji,
Shibasaki Masahiro,
Ohkuma Seitaro
Publication year - 2012
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20997
Subject(s) - nucleus accumbens , conditioned place preference , dopamine , dopamine receptor , receptor , chemistry , sulpiride , dopamine receptor d2 , pharmacology , neuroscience , endocrinology , medicine , psychology , biology , dopaminergic , biochemistry
Recent study shows that type 1 inositol‐1,4,5‐triphosohate receptors (IP 3 Rs) may be involved in amphetamine‐induced conditioned preference, but little is known about its role in psychological dependence on cocaine. This study investigated the role and regulation of IP 3 R‐1 in mice with cocaine‐induced place preference. The cocaine‐induced place preference was dose‐dependently inhibited by intracerebroventricular pretreatment with IP 3 R antagonists, 2‐aminophenoxyethane‐borate (2‐APB), and xestospongin C. The levels of IP 3 R‐1 in the frontal cortex and nucleus accumbens of cocaine‐conditioned mice significantly increased, which was completely abolished by SCH23390 and sulpiride, selective dopamine D1 and D2 receptor antagonists, respectively. These findings suggest that IP 3 R‐1‐mediated intracellular signaling pathway may play an important role in the development of cocaine‐induced place preference and that the expression of IP 3 R‐1 is controlled by both dopamine D1 and D2 receptors in the frontal cortex and nucleus accumbens of mice with cocaine‐induced place preference. Synapse, 2012. © 2011 Wiley Periodicals, Inc.