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COMT Val 158 met genotype and striatal D 2/3 receptor binding in adults with 22q11 deletion syndrome
Author(s) -
Boot Erik,
Booij Jan,
Zinkstok Janneke R.,
Baas Frank,
Swillen Ann,
Owen Michael J.,
Murphy Declan G.,
Murphy Kieran C.,
Linszen Don H.,
Van Amelsvoort Thérèse A.
Publication year - 2011
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20932
Subject(s) - catechol o methyl transferase , striatum , radioligand , ventral striatum , dopamine , prefrontal cortex , basal ganglia , genotype , medicine , psychology , receptor , neuroscience , endocrinology , biology , gene , genetics , central nervous system , cognition
Although catechol‐ O ‐methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val 158 Met) influences striatal D 2/3 R binding ratios (D 2/3 R BP ND ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D 2/3 radioligand [ 123 I]IBZM. Met hemizygotes had significantly lower mean D 2/3 R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders. Synapse, 2011. © 2011 Wiley‐Liss, Inc.