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Test–retest variability of [ 11 C]raclopride‐binding potential in nontreatment‐seeking alcoholics
Author(s) -
Yoder Karmen K.,
Albrecht Daniel S.,
Kareken David A.,
Federici Lauren M.,
Perry Kevin M.,
Patton Elizabeth A.,
Zheng QiHuang,
Mock Bruce H.,
O'Connor Sean,
Herring Christine M.
Publication year - 2011
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20874
Subject(s) - binding potential , putamen , raclopride , intraclass correlation , psychology , ventral striatum , striatum , reproducibility , medicine , neuroscience , dopamine , developmental psychology , chemistry , psychometrics , chromatography
Abstract Knowledge of the reproducibility of striatal [ 11 C]raclopride (RAC) binding is important for studies that use RAC PET paradigms to estimate changes in striatal dopamine (DA) during pharmacological and cognitive challenges. To our knowledge, no baseline test–retest data exist for nontreatment‐seeking alcoholics (NTS). We determined the test–retest reproducibility of baseline RAC binding potential (BP ND ) in 12 male NTS subjects. Subjects were scanned twice with single‐bolus RAC PET on separate days. Striatal RAC BP (BP ND ) for left and right dorsal caudate, dorsal putamen, and ventral striatum was estimated using the Multilinear Reference Tissue Method (MRTM) and Logan Graphical Analysis (LGA) with a reference region. Test–retest variability (TRV), % change in BP ND between scan days, and the intraclass correlation coefficient (ICC) were used as metrics of reproducibility. For MRTM, TRV for striatal RAC binding in NTS subjects was ±6.5% and ±7.1% for LGA. Average striatal ICCs were 0.94 for both methods ( P < 0.0001). Striatal BP ND values were similar to those reported previously for detoxified alcoholics. The results demonstrate that baseline striatal RAC binding is highly reproducible in NTS subjects, with a low variance similar to that reported for healthy control subjects. Synapse, 2011. © 2010 Wiley‐Liss, Inc.