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Distribution of CB2 cannabinoid receptor in adult rat retina
Author(s) -
López Ester M.,
Tagliaferro Patricia,
Onaivi Emmanuel S.,
LópezCosta Juan J.
Publication year - 2011
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20856
Subject(s) - inner plexiform layer , inner nuclear layer , retina , outer plexiform layer , cannabinoid receptor , cannabinoid receptor type 2 , microbiology and biotechnology , immunocytochemistry , ganglion cell layer , neuroscience , amacrine cell , chemistry , gabaergic , cannabinoid , biology , receptor , endocrinology , biochemistry , agonist , inhibitory postsynaptic potential
Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT‐PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT‐PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse, 2010. © 2010 Wiley‐Liss, Inc.