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Cocaine self‐administration markedly increases dopamine D 2 receptor negative cooperativity for dopamine binding: A receptor dimer‐based analysis
Author(s) -
Franco Rafael,
Seeman Philip,
Barrera Carlos,
Aymerich Maria S.
Publication year - 2010
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20775
Subject(s) - dopamine , receptor , dopamine receptor , agonist , chemistry , fenoldopam , domperidone , dopamine agonist , endogenous agonist , endocrinology , pharmacology , biophysics , dopamine receptor d1 , medicine , biology , biochemistry
The proportion of dopamine D 2 High receptors has been reported to increase after cocaine self‐administration without a significant change in the total number of D 2 receptors. In the present article, the data of competition by dopamine of [ 3 H]domperidone binding to striatal samples from naïve and cocaine‐addicted animals (Briand et al., [2008] Eur Neuropsychopharmacol 18:551–556) are analyzed assuming that D 2 receptors are constitutive dimers. The results show another way of interpreting those previous results and lead to the finding that cocaine affects agonist affinity and may strongly affect the receptor‐receptor cooperation between dimers, a result that can contribute to dopamine supersensitivity. Synapse 64:566–569, 2010. © 2010 Wiley‐Liss, Inc.