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Visualizing vesicular dopamine dynamics in Parkinson's disease
Author(s) -
de la FuenteFernández Raúl,
Sossi Vesna,
McCormick Siobhan,
Schulzer Michael,
Ruth Thomas J.,
Stoessl A. Jon
Publication year - 2009
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20653
Subject(s) - dopamine , levodopa , parkinson's disease , vesicular monoamine transporter , neuroscience , chemistry , endogeny , vesicular transport protein , dopaminergic , medicine , biology , disease , biochemistry , monoamine neurotransmitter , vesicle , receptor , membrane , serotonin
Abstract It has been suggested that dopamine derived from exogenous levodopa may not follow vesicular dynamics in Parkinson's disease (PD). Using a novel PET method based on the sensitivity of [ 11 C]‐dihydrotetrabenazine (DTBZ) binding to changes in vesicular dopamine levels, we show here that striatal [ 11 C]‐DTBZ binding decreases after levodopa administration in advanced PD, likely reflecting an increase in vesicular dopamine levels. Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics. Synapse 63:713–716, 2009. © 2009 Wiley‐Liss, Inc.