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Dose‐dependent changes in the synaptic strength on dopamine neurons and locomotor activity after cocaine exposure
Author(s) -
Wanat M.J.,
Bonci A.
Publication year - 2008
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20546
Subject(s) - ventral tegmental area , dopamine , glutamatergic , neuroscience , sensitization , excitatory postsynaptic potential , behavioral sensitization , neurotransmission , dopamine uptake inhibitors , addiction , synapse , locomotor activity , glutamate receptor , psychology , pharmacology , medicine , dopaminergic , nucleus accumbens , inhibitory postsynaptic potential , receptor
Changes in synaptic strength on ventral tegmental area (VTA) dopamine neurons are thought to play a critical role in the development of addiction‐related behaviors. However, it is unknown how a single injection of cocaine at different doses affects locomotor activity, behavioral sensitization, and glutamatergic synaptic strength on VTA dopamine neurons in mice. We observed that behavioral sensitization to a challenge cocaine injection scaled with the dose of cocaine received 1 day prior. Interestingly, the locomotor activity after the initial exposure to different doses of cocaine corresponded to the changes in glutamatergic strength on VTA dopamine neurons. These results in mice suggest that a single exposure to cocaine dose‐dependently affects excitatory synapses on VTA dopamine neurons, and that this acute synaptic alteration is directly associated with the locomotor responses to cocaine and not to behavioral sensitization. Synapse 62:790–795, 2008. © 2008 Wiley‐Liss, Inc.