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Dopamine D2 High receptors moderately elevated by sertindole
Author(s) -
Seeman Philip
Publication year - 2008
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20498
Subject(s) - sertindole , dopamine receptor d2 , dopamine , haloperidol , dopamine receptor , antipsychotic , receptor , medicine , endocrinology , population , chemistry , pharmacology , schizophrenia (object oriented programming) , psychiatry , environmental health
Because long‐term administration of antipsychotics can cause behavioral dopamine supersensitivity, this study examined whether the antipsychotic sertindole could elicit biochemical changes indicative of dopamine supersensitivity. In rats, behavioral dopamine supersensitivity is consistently associated with an increased proportion of dopamine receptors that have high affinity for dopamine, namely D2 High , in homogenized striata. Nine days of subcutaneously injected sertindole (1.25 mg/kg/day) increased the proportion of D2 High receptors between 186% and 215%, although the total population of D2 receptors did not change. Although the findings suggest that rats or patients treated with sertindole might exhibit behavioral dopamine supersensitivity, the drug‐induced increase in D2 High receptors was less than that previously found with haloperidol. Synapse 62:389–393, 2008. © 2008 Wiley‐Liss, Inc.