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Regulation of neuronal cdc20 ( p 55cdc) expression by the plasticity‐related transcription factor zif268
Author(s) -
Conway AnnMarie,
James Allan B.,
Zang Jie,
Morris Brian J.
Publication year - 2007
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20387
Subject(s) - transcription factor , egr1 , biology , microbiology and biotechnology , proteasome , synapse , neuroscience , gene , genetics
Most forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down‐regulation of cdc20 (p55 cdc )—a regulatory protein for the anaphase‐promoting complex, which controls access of specific substrates to the proteasome—was observed after transfection of a neuronal cell line with zif268. Treatment of cultured hippocampal neurones with NMDA, which elevates endogenous zif268 levels, also decreased cdc20 levels. Conversely, the levels of cdc20 were found to be increased in the cerebral cortex of mice with targeted deletion of the zif268 gene, when compared with wild‐type controls. Our findings indicate that expression of the cdc20 gene is down‐regulated by zif268 in neuronal cells, and provide new evidence that altered expression of proteasome‐regulatory genes following zif268 induction may be a key component of long‐lasting CNS plasticity. Synapse 61:463‐468, 2007. © 2007 Wiley‐Liss, Inc.