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Pharmacologically induced, subsecond dopamine transients in the caudate–putamen of the anesthetized rat
Author(s) -
Venton B. Jill,
Wightman R. Mark
Publication year - 2007
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20343
Subject(s) - nomifensine , autoreceptor , dopamine , haloperidol , dopamine transporter , putamen , chemistry , antagonist , dopamine receptor d2 , pharmacology , dopamine antagonist , neuroscience , dopaminergic , receptor , medicine , biology , biochemistry
Subsecond dopamine (DA) concentration transients have previously been observed in behaving rats. Here, we demonstrate for the first time that DA transients can be pharmacologically induced in anesthetized rats. Coadministration of the D2 receptor antagonist, haloperidol, and the DA uptake inhibitor, nomifensine, results in significantly more DA transients than either drug alone. The results show that both D2 autoreceptors and the dopamine transporter regulate subsecond DA neurotransmission. Synapse 61:37–39, 2007. © 2006 Wiley‐Liss, Inc.