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Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal
Author(s) -
Olson Valerie G.,
Griner Nicholas B.,
Heusner Carrie L.,
Palmiter Richard D.
Publication year - 2006
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20328
Subject(s) - opiate , neuropeptide y receptor , neuropeptide , somatic cell , psychology , medicine , neuroscience , receptor , gene , biology , genetics
Recent evidence suggests that neuropeptide Y (NPY) may be involved in the neurobiological responses to drugs of abuse. This study was designed to assess the possible contribution of NPY to opiate withdrawal behaviors. Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs. Synapse 60:553–556, 2006. © 2006 Wiley‐Liss, Inc.