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Effect of moderate ethanol dose on dopamine uptake in rat nucleus accumbens in vivo
Author(s) -
Jones Sara R.,
Mathews Tiffany A.,
Budygin Evgeny A.
Publication year - 2006
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20294
Subject(s) - nucleus accumbens , dopamine , chemistry , in vivo , ethanol , microelectrode , voltammetry , extracellular , pharmacology , biophysics , neuroscience , biochemistry , medicine , electrode , biology , electrochemistry , microbiology and biotechnology
The present study was designed to evaluate the effects of a moderate dose of ethanol (1 g/kg) on dopamine (DA) dynamics in rat nucleus accumbens (NAc) using fast‐scan cyclic voltammetry. Voltammetric recordings were made every 100 ms at a carbon fiber microelectrode, positioned in the NAc core. Acute ethanol did not significantly alter DA uptake parameters ( K m and V max ), but amplitudes of the DA signals were decreased after the drug in both freely moving and anesthetized rats. Therefore, the present in vivo voltammetry results suggest that DA uptake changes are not involved in ethanol‐induced increases in extracellular DA concentrations. Synapse 60:251–255, 2006. © 2006 Wiley‐Liss, Inc.