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PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy
Author(s) -
Mirrione Martine M.,
Schiffer Wynne K.,
Siddiq Mustafa,
Dewey Stephen L.,
Tsirka Stella E.
Publication year - 2006
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20216
Subject(s) - epilepsy , temporal lobe , neuroscience , positron emission tomography , pet imaging , metabolism , carbohydrate metabolism , psychology , medicine , endocrinology
Here we present the first demonstration that 2‐deoxy‐2[ 18 F]fluoro‐ D ‐glucose ( 18 FDG) and micro Positron Emission Tomography (μPET) can be used successfully to monitor regional changes in brain metabolism during acute seizure induction in C57Bl/6 mice. These longitudinal studies show a significant increase in 18 FDG uptake in the hippocampus (33.2%) which correlates directly with seizure severity ( R 2 = 0.86). 18 FDG μPET can potentially be used to monitor the development of TLE in mouse models from the acute phase of status epilepticus to the chronic phase of spontaneous recurrent seizures. These studies provide a foundation upon which we can begin to identify genetic contributions to the metabolic signature of TLE in mice, since many transgenics are in the C57Bl/6 background strain. Synapse 59: 119–121, 2006. © 2005 Wiley‐Liss, Inc.