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Environment makes amphetamine‐induced dopamine release in the nucleus accumbens totally impulse‐dependent
Author(s) -
Ventura Rossella,
PuglisiAllegra Stefano
Publication year - 2005
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20197
Subject(s) - nucleus accumbens , amphetamine , dopamine , impulse (physics) , neuroscience , sensitization , chemistry , stimulant , addiction , pharmacology , psychology , biology , physics , quantum mechanics
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food‐restricted DBA/2J mice lose the impulse‐independent component of psychostimulant‐induced dopamine release in the nucleus accumbens that is replaced totally by impulse‐dependent dopamine release. These results indicate for the first time that the crucial effect of environment‐induced sensitization is a dramatic increase of the impulse dependent component. Synapse 58:211–214, 2005. © 2005 Wiley‐Liss, Inc.