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Decreased cell proliferation in the dentate gyrus of rats after repeated administration of cocaine
Author(s) -
Yamaguchi Mika,
Suzuki Toshihito,
Seki Tatsunori,
Namba Takashi,
Liu Juan,
Arai Heii,
Hori Takafumi,
Shiga Takashi
Publication year - 2005
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20182
Subject(s) - dentate gyrus , hippocampal formation , stereotypy , hippocampus , sensitization , neuroscience , pharmacology , medicine , endocrinology , psychology , amphetamine , dopamine
Cell proliferation in the dentate gyrus of hippocampus was assessed using in vivo labeling with 5‐bromo‐2′‐deoxyuridine (BrdU) in adult rats that were administered cocaine (20 mg/kg) for 14 consecutive days. Rats showed increased stereotypy at a challenge dose of cocaine after 1 week of withdrawal, suggesting the acquisition of behavioral sensitization. Twenty‐four hours after final injection of repetitive cocaine administration, a 26% decrease in BrdU‐positive cells was observed, compared with control rats. However, this returned to control level within 1 week. No differences were observed in rats that received a single injection of cocaine. Differentiation of newly formed cells was not influenced. These data imply that the regulation of hippocampal cell proliferation by cocaine may be involved in the development of certain symptoms of addiction, such as cognitive impairment and acquisition of behavioral sensitization. Synapse 58:63–71, 2005. © 2005 Wiley‐Liss, Inc.