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Effects of corticotropin‐releasing hormone receptor antagonists on cocaine‐induced dopamine overflow in the medial prefrontal cortex and nucleus accumbens of rats
Author(s) -
Gurkovskaya Olga V.,
Palamarchouk Vitaly,
Smagin Gennady,
Goeders Nick E.
Publication year - 2005
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20172
Subject(s) - nucleus accumbens , dopamine , dopaminergic , prefrontal cortex , corticotropin releasing hormone , neuroscience , microdialysis , hypothalamus , chemistry , psychology , endocrinology , medicine , biology , cognition
Recent evidence suggests an important role for corticotropin‐releasing hormone (CRH) and CRH receptors in cocaine reinforcement. CRH receptor antagonists reduce cocaine self‐administration and attenuate the reinstatement of extinguished cocaine‐seeking behavior, but little is known about the mechanisms involved. One possible mechanism for these effects may involve the cocaine‐induced activation of CRH located in brain regions outside of the hypothalamus. CRH has been shown to increase dopaminergic transmission in regions relevant for cocaine reinforcement, such as the medial prefrontal cortex and the nucleus accumbens. Here, we report that CP‐154,526, a CRH1‐receptor antagonist, actually enhances cocaine‐induced increases in dopamine overflow in the medial prefrontal cortex, measured using in vivo microdialysis. In contrast, the receptor antagonist did not alter cocaine‐induced increases in dopamine in most of the nucleus accumbens, except for the most rostral part. These data suggest a surprising role for prefrontal cortex dopamine in the ability of CRH‐receptor antagonists to attenuate cocaine seeking in rats. Synapse 57:202–212, 2005. © 2005 Wiley‐Liss, Inc.