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Phospholipase Cγ in distinct regions of the ventral tegmental area differentially regulates morphine‐induced locomotor activity
Author(s) -
Bolaños Carlos A.,
Neve Rachael L.,
Nestler Eric J.
Publication year - 2005
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20136
Subject(s) - ventral tegmental area , neuroscience , microinjections , morphine , nucleus accumbens , sensitization , behavioral sensitization , phospholipase c , biology , pharmacology , dopamine , signal transduction , microbiology and biotechnology , central nervous system , dopaminergic
Neurotrophic factors and the signaling pathways they activate play a role in mediating long‐term molecular, cellular, and behavioral adaptations associated with drug addiction. Here we mimicked the biological response of phospholipase C‐γ (PLCγ) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral‐mediated gene transfer. Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLCγ1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine. Synapse 56:166–169, 2005. © 2005 Wiley‐Liss, Inc.