Upregulation of striatal adenosine A 2A  receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA | Zendy

Tomiyama Masahiko | Zendy; Kimura Tamaki | Zendy; Maeda Tetsuya | Zendy; Tanaka Hiroyasu | Zendy; Kannari Kazuya | Zendy; Baba Masayuki | Zendy

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Upregulation of striatal adenosine A 2A receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA

Author(s) -

Tomiyama Masahiko,

Kimura Tamaki,

Maeda Tetsuya,

Tanaka Hiroyasu,

Kannari Kazuya,

Baba Masayuki

Publication year - 2004

Publication title -

synapse

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.809

H-Index - 106

eISSN - 1098-2396

pISSN - 0887-4476

DOI - 10.1002/syn.20011

Subject(s) - hydroxydopamine , oxidopamine , medial forebrain bundle , dopaminergic , striatum , medicine , endocrinology , dopamine , dopamine receptor d2 , chemistry , denervation , receptor , dyskinesia , dopamine receptor d1 , dopamine receptor , parkinson's disease , substantia nigra , disease

To determine whether the adenosine A 2A receptor might play a role in L‐DOPA‐induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A 2A receptor mRNA in response to intermittent treatment with L‐DOPA in rats with dopaminergic denervation by 6‐hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L‐DOPA increased A 2A receptor mRNA levels in the dopamine‐depleted striatum of 6‐OHDA‐lesioned rats exhibiting behavioral sensitization to L‐DOPA. These results suggest that A 2A receptor activation is associated with the development of motor complications induced by L‐DOPA treatment. Synapse 52:218–222, 2004. © 2004 Wiley‐Liss, Inc.

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