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Upregulation of striatal adenosine A 2A receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA
Author(s) -
Tomiyama Masahiko,
Kimura Tamaki,
Maeda Tetsuya,
Tanaka Hiroyasu,
Kannari Kazuya,
Baba Masayuki
Publication year - 2004
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.20011
Subject(s) - hydroxydopamine , oxidopamine , medial forebrain bundle , dopaminergic , striatum , medicine , endocrinology , dopamine , dopamine receptor d2 , chemistry , denervation , receptor , dyskinesia , dopamine receptor d1 , dopamine receptor , parkinson's disease , substantia nigra , disease
To determine whether the adenosine A 2A receptor might play a role in L‐DOPA‐induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A 2A receptor mRNA in response to intermittent treatment with L‐DOPA in rats with dopaminergic denervation by 6‐hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L‐DOPA increased A 2A receptor mRNA levels in the dopamine‐depleted striatum of 6‐OHDA‐lesioned rats exhibiting behavioral sensitization to L‐DOPA. These results suggest that A 2A receptor activation is associated with the development of motor complications induced by L‐DOPA treatment. Synapse 52:218–222, 2004. © 2004 Wiley‐Liss, Inc.