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Anticocaine catalytic antibodies have no affinity for RTI compounds: Implications for treatment
Author(s) -
Kuhar Michael J.,
Carroll F. Ivy,
Bharat Narine,
Landry Donald W.
Publication year - 2001
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.1072
Subject(s) - immunogen , antibody , chemistry , pharmacology , drug , catalysis , medicine , biochemistry , immunology , monoclonal antibody
Potential medications for cocaine abusers include: anticocaine catalytic antibodies, which could serve as circulating peripheral blockers of cocaine that prevents its action in the brain; and 3‐phenyltropane cocaine analogs, which could serve as potent, selective, and long‐lasting substitutes that reduce drug‐seeking. In order to evaluate the compatibility of these agents, we measured if a catalytic antibody would bind and interact with some cocaine analogs. Anticocaine catalytic antibody 15A10 had no significant affinity for RTI‐51, RTI‐112, or RTI‐177 as examined by ELISA. They exhibited high affinity for the immunogen TSA1 in the same experiment, as expected. Because the antibody and the RTI compounds do not interact, they are candidates for simultaneous use. Synapse 41:176–178, 2001. © 2001 Wiley‐Liss, Inc.