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Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
Author(s) -
Smith Gwenn S.,
Ma Yilong,
Dhawan Vijay,
Gunduz Handan,
Carbon Maren,
Kirshner Maggie,
Larson Jennifer,
Chaly Thomas,
Belakhleff Abdel,
Kramer Elisse,
Greenwald Blaine,
Kane John M.,
LaghrissiThode Fouzia,
Pollock Bruce G.,
Eidelber David
Publication year - 2002
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.10088
Subject(s) - citalopram , precuneus , positron emission tomography , medicine , neuroscience , endocrinology , carbohydrate metabolism , serotonin , gyrus , antidepressant , psychology , anesthesia , hippocampus , functional magnetic resonance imaging , receptor
To develop a method to measure the dynamic response of the serotonin system in vivo, the effects of intravenously administered citalopram (the most selective of the serotonin reuptake inhibitors) on cerebral glucose metabolism were evaluated. Cerebral glucose metabolism was measured with positron emission tomography (PET) in 14 normal subjects scanned after administration of saline placebo and citalopram administered on 2 separate days. Citalopram administration resulted in a decrease in metabolism in the right anterior cingulate gyrus (BA 24/32), right superior (BA 9) and right middle frontal gyrus (BA 6), right parietal cortex (precuneus), right superior occipital gyrus, left thalamus, and right cerebellum. Increased metabolism was observed in the left superior temporal gyrus and left occipital cortex. Alterations in metabolism by acute citalopram administration involved the heteromodal association cortices that also show metabolic alterations in patients with geriatric depression and overlap with the regions affected by antidepressant treatment. Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression. Synapse 45:105–112, 2002. © 2002 Wiley‐Liss, Inc.