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Effect of tetrabenazine on the striatal uptake of exogenous L‐DOPA in vivo: A PET study in young and aged rhesus monkeys
Author(s) -
DeJesus Onofre T.,
Shelton Steven E.,
Roberts Andrew D.,
Nickles Robert J.,
Holden James E.
Publication year - 2002
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.10077
Subject(s) - tetrabenazine , vesicular monoamine transporter 2 , vesicular monoamine transporter , monoamine neurotransmitter , pharmacology , in vivo , dopamine , chemistry , medicine , endocrinology , dopaminergic , dopamine transporter , biology , biochemistry , serotonin , receptor , microbiology and biotechnology
The effect of tetrabenazine (TBZ) pretreatment on the striatal uptake of exogenous L‐DOPA in vivo was assessed noninvasively in rhesus monkeys by positron emission tomography (PET) using the tracer [ 18 F]‐FluoroDOPA (FDOPA). Paired studies were done comparing baseline vs. TBZ treatment on the uptake of FDOPA, a measure of aromatic L‐amino acid decarboxylase (AAAD) activity. Results show increased AAAD activity with TBZ treatment. These results suggest that the action of TBZ as a dopamine antagonist dominates more than its expected action as a potent vesicular monoamine transporter (VMAT2) inhibitor. Results also showed diminished responsivity of AAAD to TBZ challenge in aged monkey brain. Synapse 44:246–251, 2002. © 2002 Wiley‐Liss, Inc.